معمل كولد سپرنگ هاربر
Cold Spring Harbor Laboratory (CSHL) is a private, non-profit institution with research programs focusing on cancer, neuroscience, plant biology, genomics, and quantitative biology.[2]
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| تأسس | 1890 |
|---|---|
| الرئيس | Bruce Stillman |
| الطاقم | 1,200 |
| الميزانية | $150,000,000 |
| الموقع | 1 Bungtown Road، Laurel Hollow، New York، الولايات المتحدة |
| الموقع الإلكتروني | www |
Cold Spring Harbor Laboratory Historic District | |
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| الموقع | Jct. of NY 25A and Bungtown Rd., Laurel Hollow, New York |
| الإحداثيات | 40°51′43″N 73°28′2″W / 40.86194°N 73.46722°WCoordinates: 40°51′43″N 73°28′2″W / 40.86194°N 73.46722°W |
| المساحة | 100 acres (40 ha) |
| المعماري | Multiple |
| الطراز المعماري | Multiple |
| NRHP reference No. | خطأ لوا: invalid capture index %2 in replacement string. |
| أضيف إلى NRHP | March 30, 1994 |
It is one of 68 institutions supported by the Cancer Centers Program of the U.S. National Cancer Institute (NCI) and has been an NCI-designated Cancer Center since 1987.[3] The Laboratory is one of a handful of institutions that played a central role in the development of molecular genetics and molecular biology.[4]
It has been home to eight scientists who have been awarded the Nobel Prize in Physiology or Medicine. CSHL is ranked among the leading basic research institutions in molecular biology and genetics with Thomson Reuters ranking it #1 in the world.[5] The Laboratory is led by Bruce Stillman, a biochemist and cancer researcher.
Since its inception in 1890, the institution's campus on the North Shore of Long Island has also been a center of biology education. Current CSHL educational programs serve professional scientists, doctoral students in biology, teachers of biology in the K-12 system, and students from the elementary grades through high school. In the past 10 years CSHL conferences & courses have drawn over 81,000 scientists and students to the main campus.[6] For this reason, many scientists consider CSHL a "crossroads of biological science."[7] Since 2009 CSHL has partnered with the Suzhou Industrial Park in Suzhou, China to create Cold Spring Harbor Asia which annually draws some 3,000 scientists to its meetings and courses.[8]
In 2015, CSHL announced a strategic affiliation with the nearby Northwell Health to advance cancer therapeutics research, develop a new clinical cancer research unit at Northwell Health in Lake Success, NY, to support early-phase clinical studies of new cancer therapies, and recruit and train more clinician-scientists in oncology.[9]
CSHL hosts bioRxiv, the preprint repository for biologists.
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Notable faculty[10]
- Douglas Fearon, immunologist, Fellow of the Royal Society, member of the National Academy of Sciences
- Leemor Joshua-Tor, structural biologist, Howard Hughes Medical Institute investigator, National Academy of Sciences member, AAAS
- Adrian Krainer, studies RNA splicing and developed nusinersen for treatment of spinal muscular atrophy (SMA).
- Robert Martienssen, studies epigenetics, Howard Hughes Medical Institute investigator and Fellow of the Royal Society (FRS).
- Bruce Stillman, molecular biologist, Fellow of the Royal Society, Member of the National Academy of Sciences, EMBO and AAAS.
- Michael Wigler, genetic engineering of animal cells and molecular biologist, Member of the National Academy of Sciences and AAAS.
- James Watson, co-discoverer of structure of DNA, Nobel Laureate.
- Scott Lowe (currently at MSKCC), research on p53, Member of the National Academy of Sciences and investigator of Howard Hughes Medical Institute.
- Gregory Hannon (currently at CRUK Cambridge Institute), research on RNA interference, Member of the National Academy of Sciences.
- Barbara McClintock, awarded the Nobel Prize for Physiology or Medicine in 1983 for her discovery of mobile genetic elements [11][12].
Nobel Prize winners
- Carol Greider, discovered relationship between cellular aging and damage to the ends of chromosomes, called telomeres, in 1992; won Nobel Prize in 2009 with Elizabeth Blackburn and Jack W. Szostak[13]
- Barbara McClintock, discovered transposons ("jumping genes") in 1944; received Nobel Prize in 1983[14]
- Martha Chase and Alfred Hershey, conducted "Waring blender experiments", confirmed DNA as the genetic material in 1952;[15] won Nobel Prize with Salvador Luria and Max Delbrück in 1969[16]
- James D. Watson, CSHL Director from 1968 to 1993, shared a Nobel Prize with Francis Crick and Maurice Wilkins in 1962 for their discovery of the double helix structure of DNA.[17]
- Richard J. Roberts and Phillip A. Sharp shared a Nobel in 1993 for the discovery of discontinuous, or "split" genes, which revealed the RNA splicing mechanism.[18]
See also
Notes and references
- ^ "National Register Information System". National Register of Historic Places. National Park Service. مارس 13, 2009.
- ^ As described here: [1] and here: [2]
- ^ [3]
- ^ Horace Freedland Judson, The Eighth Day of Creation: The Makers of the Revolution in Biology (Simon & Schuster, 1979), esp. pp. 65-69; also: 44-46; 53; 57-58; 62; 70; 82; 185; 232; 239; 247; 273; 321; 368; 392; 454; 458-59; 572-73.
- ^ See Thompson Reuters Essential Science Indicators, [4]. The ranking is based on average citation frequency of faculty research papers published between January 2002 and December 2012. (96.94 citations of each CSHL paper, average.)
- ^ WebServices. "CSHL Facts & Figures - About Us". Archived from the original on 2014-03-22. Retrieved 2014-03-14.
{{cite web}}: Unknown parameter|dead-url=ignored (|url-status=suggested) (help) - ^ Examples include: Francis Collins, M.D., Ph.D., current director of the U.S. National Institutes of Health: [5]; Nobel laureate Sydney Brenner: [6]; Nobel laureate Eric Kandel, M.D., referring to the institutional setting of CSHL's graduate school: [7]; See also: R. Sanders Williams, "Sputnik, Slime Molds, and Botticelli in the Making of a Physician-Scientist," in David A. Schwartz, ed., Medicine, Science and Dreams: The Making of Physician-Scientists (Springer, 2010, p. 103.)
- ^ "CSH Asia Overview". www.csh-asia.org.
- ^ Dagnia Zeidlickis. "CSHL Cold Spring Harbor Laboratory and North Shore-LIJ announce strategic affiliation to accelerate benefits of cancer research to patients - News & Features".
- ^ "Faculty & Staff - Cold Spring Harbor Laboratory". Cold Spring Harbor Laboratory (in الإنجليزية الأمريكية). Retrieved 2018-08-23.
- ^ https://www.nobelprize.org/prizes/medicine/1983/summary/
- ^ http://library.cshl.edu/personal-collections/barbara-mcclintock
- ^ "The Nobel Prize in Physiology or Medicine 2009".
- ^ [8] See the classic paper McClintock B 1951 "Chromosome Organization and Genic Expression" (Cold Spring Harbor Symp. Quant. Biol 16: 13-47).
- ^ A.D. Hershey and Martha Chase, "Independent Functions of Viral Protein and Nucleic Acid in Growth of Bacteriophage," J. General Physiology (September 20, 1952) 36:1, 39-56.
- ^ "The Nobel Prize in Physiology or Medicine 1969".
- ^ "The Nobel Prize in Physiology or Medicine 1962".
- ^ "The Nobel Prize in Physiology or Medicine 1993".