قالب:PBB/324

السليلة القولونية الغدية Adenomatous polyposis coli
PDB rendering based on 1deb.
البنى المتاحة
1DEB, 1EMU, 1JPP, 1M5I, 1T08, 1TH1, 1V18, 2RQU, 3AU3, 3NMW, 3NMX, 3NMZ, 3QHE, 3RL7, 3RL8, 3T7U, 4G69
المحددات
الرمزs	APC; BTPS2; DP2; DP2.5; DP3; GS; PPP1R46
المحددات الخارجية	OMIM: 611731 MGI: 88039 هومولوجين: 30950 GeneCards: APC Gene
طبيعة الجين الوظيفة الجزيئية • protein binding • beta-catenin binding • microtubule binding • protein kinase regulator activity • protein kinase binding • gamma-catenin binding • cadherin binding • microtubule plus-end binding المكون الخلوي • kinetochore • nucleus • cytoplasm • centrosome • cytosol • cytoplasmic microtubule • plasma membrane • cell-cell adherens junction • tight junction • lateral plasma membrane • lamellipodium • beta-catenin destruction complex • ruffle membrane • microtubule plus-end • axonal growth cone العملية الحيوية • mitotic cytokinesis • kidney development • hair follicle development • protein complex assembly • apoptotic process • cellular component disassembly involved in execution phase of apoptosis • cellular response to DNA damage stimulus • negative regulation of microtubule depolymerization • cell cycle arrest • metaphase/anaphase transition of mitotic cell cycle • mitotic spindle assembly checkpoint • cell adhesion • axonogenesis • negative regulation of cell proliferation • axis specification • anterior/posterior pattern specification • dorsal/ventral pattern formation • proximal/distal pattern formation • cell migration • positive regulation of cell migration • positive regulation of epithelial cell differentiation • positive regulation of microtubule polymerization • cytoplasmic microtubule organization • positive regulation of pseudopodium assembly • regulation of microtubule-based process • T cell differentiation in thymus • somatic stem cell maintenance • negative regulation of odontogenesis • positive regulation of apoptotic process • negative regulation of MAPK cascade • canonical Wnt signaling pathway involved in negative regulation of apoptotic process • canonical Wnt signaling pathway involved in positive regulation of apoptotic process • regulation of osteoblast differentiation • regulation of osteoclast differentiation • positive regulation of protein catabolic process • negative regulation of cyclin-dependent protein serine/threonine kinase activity • positive regulation of cell adhesion • muscle cell cellular homeostasis • thymus development • regulation of nitrogen compound metabolic process • chromosome organization • positive regulation of cell division • regulation of attachment of spindle microtubules to kinetochore • retina development in camera-type eye • canonical Wnt signaling pathway • negative regulation of epithelial cell proliferation involved in prostate gland development • tight junction assembly • negative regulation of canonical Wnt signaling pathway
نمط تعبير الرنا
المزيد من التعبيرات المرجعية
الكروموسومات المتناددة Orthologs
النوع	بشري	فأري
Entrez	324	11789
Ensembl	ENSG00000134982	ENSMUSG00000005871
UniProt	P25054	n/a
RefSeq (mRNA)	NM_000038	NM_007462
RefSeq (protein)	NP_000029	NP_031488
الموقع (UCSC)	Chr 5: 112.04 - 112.18 Mb	Chr 18: 34.22 - 34.32 Mb
بحث PubMed	[1]	[2]