افتح القائمة الرئيسية
الصفحة الرئيسية
عشوائي
دخول
الإعدادات
عن المعرفة
عدم مسؤولية
المعرفة
بحث
قالب
:
PBB/23411
راقب هذه الصفحة
عدل
<
قالب:PBB
Sirtuin 1
البنى المتاحة
4I5I
,
4IF6
,
4IG9
,
4KXQ
المحددات
الرمزs
SIRT1
; SIR2L1
المحددات الخارجية
OMIM:
604479
MGI
:
2135607
هومولوجين
:
56556
GeneCards
:
SIRT1 Gene
طبيعة الجين
الوظيفة الجزيئية
•
p53 binding
•
transcription corepressor activity
•
NAD+ ADP-ribosyltransferase activity
•
histone deacetylase activity
•
protein binding
•
protein C-terminus binding
•
NAD-dependent histone deacetylase activity
•
deacetylase activity
•
protein deacetylase activity
•
NAD-dependent protein deacetylase activity
•
histone binding
•
identical protein binding
•
HLH domain binding
•
bHLH transcription factor binding
•
metal ion binding
•
NAD-dependent histone deacetylase activity (H3-K9 specific)
•
mitogen-activated protein kinase binding
•
NAD+ binding
المكون الخلوي
•
nuclear chromatin
•
nucleus
•
nuclear envelope
•
nuclear inner membrane
•
nucleoplasm
•
chromatin silencing complex
•
nuclear euchromatin
•
nuclear heterochromatin
•
nucleolus
•
cytoplasm
•
PML body
•
rDNA heterochromatin
•
ESC/E(Z) complex
العملية الحيوية
•
single strand break repair
•
negative regulation of transcription from RNA polymerase II promoter
•
chromatin silencing at rDNA
•
pyrimidine dimer repair by nucleotide-excision repair
•
DNA synthesis involved in DNA repair
•
angiogenesis
•
ovulation from ovarian follicle
•
cellular glucose homeostasis
•
positive regulation of protein phosphorylation
•
positive regulation of adaptive immune response
•
DNA replication
•
DNA repair
•
chromatin silencing
•
establishment of chromatin silencing
•
maintenance of chromatin silencing
•
methylation-dependent chromatin silencing
•
transcription, DNA-dependent
•
rRNA processing
•
protein ADP-ribosylation
•
protein deacetylation
•
triglyceride mobilization
•
response to DNA damage stimulus
•
response to oxidative stress
•
spermatogenesis
•
regulation of mitotic cell cycle
•
muscle organ development
•
cell aging
•
positive regulation of cell proliferation
•
cellular response to starvation
•
positive regulation of cholesterol efflux
•
regulation of glucose metabolic process
•
positive regulation of macroautophagy
•
protein ubiquitination
•
histone deacetylation
•
peptidyl-lysine acetylation
•
virus-host interaction
•
negative regulation of cell growth
•
negative regulation of transforming growth factor beta receptor signaling pathway
•
negative regulation of prostaglandin biosynthetic process
•
protein destabilization
•
positive regulation of chromatin silencing
•
negative regulation of TOR signaling cascade
•
regulation of endodeoxyribonuclease activity
•
negative regulation of NF-kappaB transcription factor activity
•
response to insulin stimulus
•
regulation of protein import into nucleus, translocation
•
regulation of smooth muscle cell apoptotic process
•
peptidyl-lysine deacetylation
•
cellular triglyceride homeostasis
•
regulation of peroxisome proliferator activated receptor signaling pathway
•
regulation of cell proliferation
•
negative regulation of phosphorylation
•
cholesterol homeostasis
•
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
•
regulation of apoptotic process
•
positive regulation of apoptotic process
•
negative regulation of apoptotic process
•
negative regulation of I-kappaB kinase/NF-kappaB cascade
•
proteasomal ubiquitin-dependent protein catabolic process
•
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
•
negative regulation of sequence-specific DNA binding transcription factor activity
•
negative regulation of DNA damage response, signal transduction by p53 class mediator
•
positive regulation of MHC class II biosynthetic process
•
negative regulation of fat cell differentiation
•
positive regulation of DNA repair
•
negative regulation of transcription, DNA-dependent
•
positive regulation of transcription from RNA polymerase II promoter
•
positive regulation of insulin receptor signaling pathway
•
white fat cell differentiation
•
negative regulation of helicase activity
•
negative regulation of protein kinase B signaling cascade
•
fatty acid homeostasis
•
negative regulation of androgen receptor signaling pathway
•
cellular response to hydrogen peroxide
•
regulation of bile acid biosynthetic process
•
histone H3 deacetylation
•
cellular response to tumor necrosis factor
•
cellular response to hypoxia
•
cellular response to ionizing radiation
•
regulation of response to stress
•
positive regulation of macrophage apoptotic process
•
negative regulation of cAMP-dependent protein kinase activity
•
positive regulation of cAMP-dependent protein kinase activity
•
negative regulation of cellular response to testosterone stimulus
•
negative regulation of peptidyl-lysine acetylation
•
negative regulation of cellular senescence
•
positive regulation of cellular senescence
نمط تعبير الرنا
المزيد من التعبيرات المرجعية
الكروموسومات المتناددة Orthologs
النوع
بشري
فأري
Entrez
23411
93759
Ensembl
ENSG00000096717
ENSMUSG00000020063
UniProt
Q96EB6
Q923E4
RefSeq (mRNA)
NM_001142498
NM_001159589
RefSeq (protein)
NP_001135970
NP_001153061
الموقع (UCSC)
Chr 10:
69.64 - 69.68 Mb
Chr 10:
63.32 - 63.38 Mb
بحث
PubMed
[1]
[2]