افتح القائمة الرئيسية
الصفحة الرئيسية
عشوائي
دخول
الإعدادات
عن المعرفة
عدم مسؤولية
المعرفة
بحث
قالب
:
PBB/23405
راقب هذه الصفحة
عدل
<
قالب:PBB
Dicer 1, ribonuclease type III
Structure of RNaseIIIb and dsRNA binding domains of mouse Dicer
البنى المتاحة
2EB1
,
4NGB
,
4NGC
,
4NGD
,
4NGF
,
4NGG
,
4NH3
,
4NH5
,
4NH6
,
4NHA
,
4WYQ
المحددات
الرمزs
DICER1
; DCR1; Dicer; Dicer1e; HERNA; K12H4.8-LIKE; MNG1; RMSE2
المحددات الخارجية
OMIM:
606241
MGI
:
2177178
هومولوجين
:
13251
GeneCards
:
DICER1 Gene
EC number
3.1.26.3
طبيعة الجين
الوظيفة الجزيئية
•
DNA binding
•
double-stranded RNA binding
•
helicase activity
•
endoribonuclease activity
•
ribonuclease III activity
•
deoxyribonuclease I activity
•
protein binding
•
ATP binding
•
protein domain specific binding
•
siRNA binding
•
miRNA binding
•
metal ion binding
•
pre-miRNA binding
المكون الخلوي
•
nucleus
•
cytoplasm
•
endoplasmic reticulum-Golgi intermediate compartment
•
cytosol
•
RISC complex
•
axon
•
dendrite
•
growth cone
•
ARC complex
•
micro-ribonucleoprotein complex
•
RISC-loading complex
العملية الحيوية
•
negative regulation of transcription from RNA polymerase II promoter
•
angiogenesis
•
apoptotic DNA fragmentation
•
post-embryonic development
•
zygote asymmetric cell division
•
gene expression
•
negative regulation of Schwann cell proliferation
•
positive regulation of gene expression
•
regulation of muscle cell apoptotic process
•
positive regulation of Schwann cell differentiation
•
myoblast differentiation involved in skeletal muscle regeneration
•
stem cell maintenance
•
spinal cord motor neuron differentiation
•
nerve development
•
olfactory bulb interneuron differentiation
•
cerebral cortex development
•
lung development
•
production of siRNA involved in RNA interference
•
targeting of mRNA for destruction involved in RNA interference
•
pre-miRNA processing
•
hair follicle morphogenesis
•
positive regulation of myelination
•
peripheral nervous system myelin formation
•
conversion of ds siRNA to ss siRNA involved in RNA interference
•
siRNA loading onto RISC involved in RNA interference
•
embryonic hindlimb morphogenesis
•
production of miRNAs involved in gene silencing by miRNA
•
multicellular organism growth
•
miRNA loading onto RISC involved in gene silencing by miRNA
•
conversion of ds siRNA to ss siRNA
•
regulation of viral genome replication
•
regulation of neuron differentiation
•
mRNA stabilization
•
spleen development
•
reproductive structure development
•
regulation of oligodendrocyte differentiation
•
branching morphogenesis of an epithelial tube
•
neuron projection morphogenesis
•
cartilage development
•
spindle assembly
•
defense response to virus
•
regulation of cell cycle
•
cardiac muscle cell development
•
inner ear receptor cell development
•
intestinal epithelial cell development
•
cardiac neural crest cell development involved in outflow tract morphogenesis
•
ganglion development
•
regulation of enamel mineralization
•
hair follicle cell proliferation
•
RNA phosphodiester bond hydrolysis, endonucleolytic
•
positive regulation of miRNA metabolic process
نطاقات الپروتين
الكروموسومات المتناددة Orthologs
النوع
بشري
فأري
Entrez
23405
192119
Ensembl
ENSG00000100697
ENSMUSG00000041415
UniProt
Q9UPY3
Q8R418
RefSeq (mRNA)
NM_001195573
NM_148948
RefSeq (protein)
NP_001182502
NP_683750
الموقع (UCSC)
Chr 14:
95.09 - 95.16 Mb
Chr 12:
104.69 - 104.75 Mb
بحث
PubMed
[1]
[2]