المعرفة

ترپسن

ترپسن أو تريبسين (Trypsin) هو انزيم يوجد في الجهاز الهضمي للعديد من الفقاريات حيث يساهم في تحفيز تفاعل تفكيك البروتين في الطعام تمهيدا لهضمه. ينتج التريبسن في البنكرياس بصيغته الغير نشطة التي تسمى تربسونيجن التي يتم فرزها في الإثنا عشري في الأمعاء الدقيقة ثم يتم تفعيله إلى الصيغة الفعالة من الانزيم والتي تسمى تربسن.

Trypsin
Identifiers
EC number 3.4.21.4
CAS number 9002-07-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
1UTN.png
Crystal structure of bovine trypsin.[1]
Trypsin
المميزات
الرمز Trypsin
Pfam PF00089
InterPro IPR001254
SMART SM00020
PROSITE PDOC00124
SCOP 1c2g
توجد بُنى في PDB:

1uvu,H:367-615; 1hrt,H:367-616; 1bbr,E:517-616; 1tbq,K:367-616; 1ucy,E:517-616; 1uvt,H:367-616; 1tbr,H:367-616; 1a0h,E:367-616; 1etr,H:367-616; 1id5,H:367-616; 1ets,H:367-616; 1ett,H:367-616; 2a1d,F:367-616; 1dwc,H:364-613; 1rd3,D:364-613; 1hlt,H:364-613; 1qvh,E:364-613; 1h8i,H:364-613; 1nrq,H:364-613; 1jou,B:364-613; 1lhf,H:364-613; 1sg8,B:364-613; 1ny2,2:364-613; 1afe,H:364-613; 1de7,K:364-613; 1a3b,H:364-613; 1ghx,H:364-613; 1hap,H:364-613; 1dm4,B:364-613; 1dx5,P:364-613; 1bhx,F:518-613; 1riw,B:364-510; 1hxe,H:364-613; 1xmn,B:364-613; 1ktt,B:364-613; 1vr1,H:364-613; 1g30,B:364-613; 1a46,H:364-613; 1bmm,H:364-613; 1tmt,H:364-613; 1c4u,2:364-613; 1tq0,B:364-613; 1bb0,B:364-613; 1bth,H:364-613; 1nt1,A:364-613; 1ghv,H:364-613; 1shh,B:364-613; 1nu7,B:364-613; 1lhd,H:364-613; 1ypm,H:364-613; 1uvs,H:364-613; 1c1u,H:364-613; 1g32,B:364-613; 1gj4,H:364-613; 1hao,H:364-613; 1iht,H:364-613; 1z8i,B:364-613; 1awh,D:364-613; 1qj1,B:364-613; 1g37,A:364-613; 1tmu,H:364-613; 1d3p,B:364-613; 1uma,H:364-613; 1tq7,B:364-613; 1zgv,A:364-613; 1d9i,A:364-613; 1dwe,H:364-613; 1o0d,H:364-613; 1ae8,H:364-613; 1nzq,H:364-613; 1gj5,H:364-613; 1nu9,D:364-613; 1d6w,A:364-613; 1e0f,D:364-613; 1lhe,H:364-613; 1t4u,H:364-613; 1abi,H:364-613; 1c1w,H:364-613; 2hpp,H:364-613; 2hpq,H:364-613; 1no9,H:364-613; 1dit,H:364-613; 1nrr,H:364-613; 1qbv,H:364-613; 2hnt,F:520-613; 1o5g,H:364-613; 1zrb,A:364-613; 1c5l,H:364-613; 1eb1,H:364-613; 1xm1,A:364-613; 1a5g,H:364-613; 1nrp,H:364-613; 1nro,H:364-613; 1sr5,C:364-613; 2afq,D:364-613; 1c4y,2:364-613; 1jwt,A:364-613; 1ypg,H:364-613; 1c5o,H:364-613; 1qj6,B:364-613; 1b5g,H:364-613; 1hah,H:364-613; 1lhg,H:364-613; 1a2c,H:364-613; 1c5n,H:364-613; 1sl3,A:364-613; 1ths,H:364-613; 1mu6,B:364-613; 1bmn,H:364-613; 1nrn,H:364-613; 1fpc,H:364-613; 1sfq,E:364-613; 1qur,H:364-613; 1hbt,H:364-613; 1ype,H:364-613; 1jmo,H:364-613; 1ta6,A:364-613; 4htc,H:364-613; 1aht,H:364-613; 1k22,H:364-613; 1d3d,B:364-613; 1ppb,H:364-613; 1nm6,A:364-613; 1a3e,H:364-613; 1ai8,H:364-613; 1mue,B:364-613; 1ca8,B:364-613; 1eol,A:364-613; 1sb1,H:364-613; 1dwb,H:364-613; 1aix,H:364-613; 7kme,H:364-613; 3hat,H:364-613; 1hxf,H:364-613; 1hdt,H:364-613; 1qj7,B:364-613; 1zgi,A:364-613; 1way,B:364-613; 1mh0,A:364-613; 1b7x,B:364-613; 1kts,B:364-613; 1ghy,H:364-613; 2hgt,H:364-613; 1k21,H:364-613; 1hut,H:364-613; 1sgi,B:364-613; 1abj,H:364-613; 1lhc,H:364-613; 1o2g,H:364-613; 1ypk,H:364-613; 1ay6,H:364-613; 1thp,B:364-613; 1qhr,B:364-613; 1z8j,B:364-613; 1hag,E:364-613; 5gds,H:364-613; 1bcu,H:364-613; 1d4p,B:364-613; 1doj,A:364-613; 1tom,H:364-613; 1p8v,C:364-613; 1h8d,H:364-613; 1tbz,H:364-613; 1tb6,H:364-613; 1dwd,H:364-613; 1ihs,H:364-613; 2thf,B:364-613; 1c4v,2:364-613; 1ba8,B:364-613; 1ypj,H:364-613; 1a4w,H:364-613; 1ook,B:364-613; 1hgt,H:364-613; 1nrs,H:364-613; 1twx,B:364-613; 1ypl,H:364-613; 4thn,H:364-613; 1t4v,H:364-613; 1tmb,H:364-613; 1d3q,B:364-613; 1vzq,H:364-613; 8kme,2:364-613; 1ta2,A:364-613; 1a61,H:364-613; 1thr,H:364-613; 1fph,H:364-613; 2a0q,B:364-613; 1ad8,H:364-613; 1mu8,B:364-613; 1ghw,H:364-613; 1c1v,H:364-613; 1d3t,B:364-613; 1awf,H:364-613; 1oyt,H:364-613; 1hai,H:364-613; 1z71,A:364-613; 1eoj,A:364-613; 1pq8,A:25-244; 1pqa,A:25-244; 1fn8,A:25-244; 1pq7,A:25-244; 1pq5,A:25-244; 1xvo,A:25-244; 1ppz,A:25-244; 1gdu,A:25-244; 1fy4,A:25-244; 1gdn,A:25-244; 1xvm,A:25-244; 1fy5,A:25-244; 1gdq,A:25-244; 1try,25-244; 1sgt,37-252; 1os8,A:37-252; 1oss,A:37-252; 1kdq,B:165-256; 1mtn,F:16-146; 1k2i,1:16-238; 1ab9,B:16-146; 1cbw,G:16-146; 1gg6,C:149-238; 1gl1,C:16-238; 6gch,G:151-238; 1ca0,H:149-238; 1t8n,C:16-238; 1ghb,F:16-146; 6cha,B:16-146; 1acb,E:16-238; 2cha,B:16-146; 2gmt,16-238; 1oxg,A:16-238; 1hja,C:149-238; 1t7c,C:16-238; 1t8o,A:16-238; 1dlk,D:16-238; 5gch,G:151-238; 5cha,B:16-146; 1p2n,A:16-238; 1gmc,F:16-146; 3gct,G:151-238; 1gmh,G:150-238; 1t8m,C:16-238; 7gch,G:151-238; 1cho,F:16-146; 1gha,G:151-238; 4vgc,C:151-238; 1cgj,E:16-238; 4cha,B:16-146; 1t8l,C:16-238; 1ex3,A:16-238; 2gch,F:16-146; 1ggd,C:149-238; 1n8o,C:149-238; 2vgc,B:16-146; 2gct,F:16-146; 1afq,B:16-146; 2cga,A:16-238; 1vgc,B:16-146; 1p2o,A:16-238; 1gmd,G:151-238; 1cgi,E:16-238; 4gch,G:151-238; 1gl0,E:16-238; 1p2m,C:16-238; 3vgc,B:16-146; 8gch,B:16-146; 1p2q,A:16-238; 1chg,16-238; 1gcd,16-238; 1fon,B:22-246; 1pyt,C:12-246; 1bru,P:29-262; 1elt,1-232; 1e38,B:27-259; 1nes,E:27-259; 2a7c,A:27-259; 1e37,B:27-259; 1haz,B:27-259; 1uvo,A:27-259; 2a7j,A:27-259; 1b0e,A:27-259; 1l0z,A:27-259; 1mcv,A:27-259; 7est,E:27-259; 4est,E:27-259; 6est,27-259; 9est,27-259; 8est,E:27-259; 2est,E:27-259; 1elf,27-259; 1qix,B:27-259; 1elc,A:27-259; 1hv7,A:27-259; 3est,27-259; 1e35,B:27-259; 2blq,A:27-259; 1c1m,A:27-259; 1qgf,A:27-259; 1inc,27-259; 1e34,B:27-259; 1uvp,A:27-259; 1hax,B:27-259; 1eat,27-259; 1l1g,A:27-259; 5est,E:27-259; 1ele,E:27-259; 1qr3,E:27-259; 1elb,A:27-259; 1hb0,B:27-259; 1uo6,A:27-259; 1okx,A:27-259; 1lvy,27-259; 1fzz,A:27-259; 1eau,27-259; 1gvk,B:27-259; 1e36,B:27-259; 1elg,27-259; 1fle,E:27-259; 2blo,A:27-259; 1est,27-259; 1eld,E:27-259; 1h9l,B:27-259; 1esb,27-259; 1eai,B:27-259; 1gwa,A:27-259; 1btu,27-259; 1qnj,A:27-259; 1lka,A:27-259; 1jim,27-259; 1lkb,A:27-259; 1mmj,N:27-259; 1hay,B:27-259; 1eas,27-259; 1ela,A:27-259; 1esa,27-259; 2d26,C:27-259; 1bma,A:27-259; 1ekb,B:801-1030; 1o5e,H:163-400; 1z8g,A:163-400; 1o5f,H:163-400; 1p57,B:163-400; 2anw,A:391-621; 2any,A:391-621; 1xxf,B:388-618; 1zjd,A:388-618; 1zhm,A:388-618; 1zhp,A:388-618; 1xxd,B:388-618; 1xx9,B:388-618; 1zhr,A:388-618; 1eaw,A:615-849; 1eax,A:615-849; 1qrz,B:581-803; 1l4d,A:581-803; 1bui,A:581-803; 1bml,B:581-803; 1ddj,C:581-803; 1rjx,B:581-803; 1l4z,A:581-803; 2bm2,B:31-267; 1a0l,A:31-267; 1aao,31-267; 1lto,A:31-267

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Isozymes

The following human genes encode proteins with trypsin enzymatic activity:

protease, serine, 1 (trypsin 1)
المميزات
الرمز PRSS1
Alt. symbols TRY1
Entrez 5644
HUGO 9475
OMIM 276000
RefSeq NM_002769
UniProt P07477
بيانات أخرى
الموقع كر. 7 q32-qter
protease, serine, 2 (trypsin 2)
المميزات
الرمز PRSS2
Alt. symbols TRYP2
Entrez 5645
HUGO 9483
OMIM 601564
RefSeq NM_002770
UniProt P07478
بيانات أخرى
الموقع كر. 7 q35
protease, serine, 3 (mesotrypsin)
المميزات
الرمز PRSS3
Alt. symbols PRSS4
Entrez 5646
HUGO 9486
OMIM 613578
RefSeq NM_002771
UniProt P35030
بيانات أخرى
الموقع كر. 9 p13

Other isoforms of trypsin may also be found in other organisms.


Clinical significance

انظر أيضاً

Trypsinization

الهامش

  1. ^ PDB 1UTN; Leiros HK, Brandsdal BO, Andersen OA, Os V, Leiros I, Helland R, Otlewski J, Willassen NP, Smalås AO (2004). "Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements". Protein Sci. 13 (4): 1056–70. doi:10.1110/ps.03498604. PMC 2280040. PMID 15044735. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

وصلات خارجية

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