التئام (طب)

سحجة باليد

Approximate day of injury
0	2	17	30

برء والتحام الجرح، هناك التئام جرح النّسيج الرّخو (كالجلد والأحشاء..) وتؤمّنه الخلايا الدّموية بتوضّعها على سداة النّسيج الضّام، وهناك إلتئام جرح النّسيج العظمي أوالجبر، يتمّ بتوضّع الكالسيوم على السّداة الضّامّية وهو ما يدعى بالتّكلّس (لتسهيله, تـثبّت بؤرة الكسر بجبيرة جبصية ممتدّة تهمّ عالية البؤرة وسافلتها, وقد يكون التّثبيث جراحيا للكسر المتعدّد البؤر).

A fluorescence micrograph of cells in Drosophila larvae healing after a puncture wound. The arrow points to cells that have fused to form syncytia, and the arrowheads point to cells that are oriented to face the wound.^[1]

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نظرة عامة لعوامل النمو المساهمة

Following are the main growth factors involved in wound healing:

عامل النمو	الاختصار	الأصول الرئيسية	التأثيرات
Epidermal growth factor	EGF	Activated macrophages Salivary glands Keratinocytes	Keratinocyte and fibroblast mitogen Keratinocyte migration Granulation tissue formation
Transforming growth factor-α	TGF-α	Activated macrophages T-lymphocytes Keratinocytes	Hepatocyte and epithelial cell proliferation
Hepatocyte growth factor	HGF	Mesenchymal cells	Epithelial and endothelial cell proliferation Hepatocyte motility
Vascular endothelial growth factor	VEGF	Mesenchymal cells	Vascular permeability Endothelial cell proliferation
Platelet derived growth factor	PDGF	Platelets Macrophages Endothelial cells Smooth muscle cells Keratinocytes	Granulocyte, macrophage, fibroblast and smooth muscle cell chemotaxis Granulocyte, macrophage and fibroblast activation Fibroblast, endothelial cell and smooth muscle cell proliferation Matrix metalloproteinase, fibronectin and hyaluronan production Angiogenesis Wound remodeling Integrin expression regulation
Fibroblast growth factor 1 and 2	FGF-1, -2	Macrophages Mast cells T-lymphocytes Endothelial cells Fibroblasts	Fibroblast chemotaxis Fibroblast and keratinocyte proliferation Keratinocyte migration Angiogenesis Wound contraction matrix deposition
Transforming growth factor-β	TGF-β	Platelets T-lymphocytes Macrophages Endothelial cells Keratinocytes Smooth muscle cells Fibroblasts	Granulocyte, macrophage, lymphocyte, fibroblast and smooth muscle cell chemotaxis TIMP synthesis Angiogenesis Fibroplasia Matrix metalloproteinase production inhibition Keratinocyte proliferation
Keratinocyte growth factor	KGF	Fibroblasts	Keratinocyte migration, proliferation and differentiation
Unless else specified in boxes, then reference is: ^[2]

انظر أيضاً

اصلاح الجلد

المصادر

^ Galko MJ, Krasnow MA (2004). "Cellular and genetic analysis of wound healing in Drosophila Larvae". PLoS Biology. 2 (8): e239. doi:10.1371/journal.pbio.0020239.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Table 3-1 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7.{{cite book}}: CS1 maint: multiple names: authors list (link) 8th edition.

وصلات خارجية

Bauer S.M., Bauer R.J., Liu Z.J., Chen H., Goldstein L., and Velázquez O.C. 2005. Vascular endothelial growth factor-C promotes vasculogenesis, angiogenesis, and collagen constriction in three-dimensional collagen gels. Journal of Vascular Surgery, 41(4): 699-707. Accessed December 31, 2006.
BioTherapeutics Education and Research Foundation
Brain S.D. 1997. Sensory neuropeptides: their role in inflammation and wound healing. Immunopharmacology, 37 (2-3): 133-152. Accessed December 31, 2006.
Ingber D. How wounds heal and tumors form Children's Hospital Boston research department.
Maggot Therapy Project web site at the University of California, Irvine, list of maggot therapy practitioners
Mustoe T. 2005. Dermal ulcer healing: Advances in understanding. Presented at meeting: Tissue repair and ulcer/wound healing: molecular mechanisms,therapeutic targets and future directions. Paris, France, March 17-18, 2005. Accessed December 31, 2006.
Revis D.R. and Seagel M.B. 2006. Skin, Grafts. Emedicine.com. Accessed December 31, 2006.
Stillman R.M. 2006. Wound Care. Emedicine.com. Accessed December 31, 2006.
Wilhelmi B.J. 2006. Wound Healing, widened and hypertrophic scars. Emedicine.com. Accessed December 31, 2006.
Journal of Burns and Wounds [1]
Fibrogenesis & Tissue Repair, an online open access journal about chronic wound healing and fibrogenesis.

[1] Galko MJ, Krasnow MA (2004). "Cellular and genetic analysis of wound healing in Drosophila Larvae". PLoS Biology. 2 (8): e239. doi:10.1371/journal.pbio.0020239.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[Kumar3-1-2] Table 3-1 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7.{{cite book}}: CS1 maint: multiple names: authors list (link) 8th edition.

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