إليزابث كاربنتر

(تم التحويل من Elizabeth P. Carpenter)
إليزابث كاربنتر
Elisabeth P. Carpenter
المدرسة الأمجامعة كمبردج
Birkbeck, University of London
السيرة العلمية
الهيئاتجامعة أكسفورد
إمپريال كولدج لندن
Diamond Light Source

Elisabeth P. Carpenter is a British structural biologist who is a professor at the Nuffield Department of Medicine in Oxford. She solved the three-dimensional structure of human membrane proteins using X-ray crystallography. Carpenter uses X-ray crystallography to understand the atomic positions within proteins.

النشأة والتعليم

Carpenter studied biochemistry at the University of Cambridge from 1981 to 1985.[1] She moved to Birkbeck, University of London for doctoral research from 1985 to 1989, where she studied biochemistry and crystallography.[1][2] After completing her doctorate, Carpenter moved to the National Institute for Health Research, which was based at Imperial College London and solved the structures of proteins involved in DNA repair.[1][2] She also investigated toxoplasmosis and muste movement.[2]

السيرة

She established the Membrane Protein Laboratory at the Diamond Light Source in 2008.[2][3][4] Subsequently, from 2009 to 2020, she worked at the Structural Genomics Consortium at the University of Oxford[1][2][5] with a focus on human membrane proteins.[6][7]

البحث العلمي

Carpenter is interested in understanding the structure and function of proteins. She studies proteins embedded within cell membranes.[2] The proteins are large hydrophobic surfaces, and understanding their structure is an important step in unravelling the processes of molecules and signals across cell membranes.[2][8]

Carpenter was the first to describe the structure of the human ABC-transporter ABC10, a mitrochonridal protein that is important in the production of heme.[9][10][11] She has studied premature ageing syndromes that are caused by failure of the lamin proteins, and the role of the metalloprotease ZMPSTE24.[12][13][14][15] She has also studied human two-pore potassium channels (K2Ps), protein that gives rise to the background leak current that contributes to membrane potential.[16][17][18][19]

منشورات مختارة

المراجع

  1. ^ أ ب ت ث "Elisabeth Paula Carpenter". ORCID. Retrieved 17 April 2026.
  2. ^ أ ب ت ث ج ح خ "Carpenter". SGC (in الإنجليزية). 2019-04-25. Retrieved 2021-09-17.
  3. ^ "New UK laboratory to focus on important medical targets - - Diamond Light Source". www.diamond.ac.uk. Retrieved 2021-09-17.
  4. ^ Barford, David; Blundell, Thomas L. (June 2022). "Dame Louise Napier Johnson. 26 September 1940—25 September 2012". Biographical Memoirs of Fellows of the Royal Society. 72: 221–250. doi:10.1098/rsbm.2021.0038.
  5. ^ Hendrickson, Wayne A (June 2016). "Atomic-level analysis of membrane-protein structure". Nature Structural & Molecular Biology. 23 (6): 464–467. doi:10.1038/nsmb.3215. PMC 5299386. PMID 27273628.
  6. ^ Carpenter, Liz. "The High-throughtput Membrane Protein Structural Biology Pipeline at the SGC" (PDF). 26th European Crystallographic Meeting, ECM 26, Darmstadt, 2010. Retrieved 17 April 2026.
  7. ^ Tampé, Robert (1 September 2015). "Membrane Transport and Communication in Frankfurt: Speakers' Summary – Highlights". Biological Chemistry. 396 (9–10): 949–954. doi:10.1515/hsz-2015-0211. PMID 26352202.
  8. ^ "Liz Carpenter". www.medsci.ox.ac.uk (in الإنجليزية). Retrieved 2021-09-17.
  9. ^ Qiu, Wei; Liesa, Marc; Carpenter, Elizabeth P.; Shirihai, Orian S. (8 June 2015). "ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione". PLOS ONE. 10 (6) e0129772. Bibcode:2015PLoSO..1029772Q. doi:10.1371/journal.pone.0129772. PMC 4459825. PMID 26053025.
  10. ^ Shum, Michael; Shintre, Chitra A.; Althoff, Thorsten; Gutierrez, Vincent; Segawa, Mayuko; Saxberg, Alexandra D.; Martinez, Melissa; Adamson, Roslin; Young, Margaret R.; Faust, Belinda; Gharakhanian, Raffi; Su, Shi; Chella Krishnan, Karthickeyan; Mahdaviani, Kiana; Veliova, Michaela; Wolf, Dane M.; Ngo, Jennifer; Nocito, Laura; Stiles, Linsey; Abramson, Jeff; Lusis, Aldons J.; Hevener, Andrea L.; Zoghbi, Maria E.; Carpenter, Elisabeth P.; Liesa, Marc (19 May 2021). "ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity". Science Translational Medicine. 13 (594) eabd1869. doi:10.1126/scitranslmed.abd1869. PMC 8300486. PMID 34011630.
  11. ^ Shintre, Chitra A.; Pike, Ashley C. W.; Li, Qiuhong; Kim, Jung-In; Barr, Alastair J.; Goubin, Solenne; Shrestha, Leela; Yang, Jing; Berridge, Georgina; Ross, Jonathan; Stansfeld, Phillip J.; Sansom, Mark S. P.; Edwards, Aled M.; Bountra, Chas; Marsden, Brian D.; von Delft, Frank; Bullock, Alex N.; Gileadi, Opher; Burgess-Brown, Nicola A.; Carpenter, Elisabeth P. (11 June 2013). "Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states". Proceedings of the National Academy of Sciences. 110 (24): 9710–9715. Bibcode:2013PNAS..110.9710S. doi:10.1073/pnas.1217042110. PMC 3683770. PMID 23716676.
  12. ^ Spear, Eric D.; Hsu, Erh-Ting; Nie, Laiyin; Carpenter, Elisabeth P.; Hrycyna, Christine A.; Michaelis, Susan (1 July 2018). "ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability". Disease Models & Mechanisms. 11 (7) dmm033670. doi:10.1242/dmm.033670. PMC 6078402. PMID 29794150.
  13. ^ Mehmood, Shahid; Marcoux, Julien; Gault, Joseph; Quigley, Andrew; Michaelis, Susan; Young, Stephen G.; Carpenter, Elisabeth P.; Robinson, Carol V. (December 2016). "Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24". Nature Chemistry. 8 (12): 1152–1158. Bibcode:2016NatCh...8.1152M. doi:10.1038/nchem.2591. PMC 5123592. PMID 27874871.
  14. ^ Babatz, Timothy D.; Spear, Eric D.; Xu, Wenxin; Sun, Olivia L.; Nie, Laiyin; Carpenter, Elisabeth P.; Michaelis, Susan (January 2021). "Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24". Journal of Biological Chemistry. 296 100165. doi:10.1074/jbc.RA120.015792. PMC 7948416. PMID 33293369.
  15. ^ Quigley, Andrew; Dong, Yin Yao; Pike, Ashley C. W.; Dong, Liang; Shrestha, Leela; Berridge, Georgina; Stansfeld, Phillip J.; Sansom, Mark S. P.; Edwards, Aled M.; Bountra, Chas; von Delft, Frank; Bullock, Alex N.; Burgess-Brown, Nicola A.; Carpenter, Elisabeth P. (29 March 2013). "The Structural Basis of ZMPSTE24-Dependent Laminopathies". Science. 339 (6127): 1604–1607. Bibcode:2013Sci...339.1604Q. doi:10.1126/science.1231513. PMID 23539603.
  16. ^ Rödström, Karin E. J.; Kiper, Aytuğ K.; Zhang, Wei; Rinné, Susanne; Pike, Ashley C. W.; Goldstein, Matthias; Conrad, Linus J.; Delbeck, Martina; Hahn, Michael G.; Meier, Heinrich; Platzk, Magdalena; Quigley, Andrew; Speedman, David; Shrestha, Leela; Mukhopadhyay, Shubhashish M. M.; Burgess-Brown, Nicola A.; Tucker, Stephen J.; Müller, Thomas; Decher, Niels; Carpenter, Elisabeth P. (18 June 2020). "A lower X-gate in TASK channels traps inhibitors within the vestibule". Nature. 582 (7812): 443–447. Bibcode:2020Natur.582..443R. doi:10.1038/s41586-020-2250-8. PMID 32499642.
  17. ^ McClenaghan, Conor; Schewe, Marcus; Aryal, Prafulla; Carpenter, Elisabeth P.; Baukrowitz, Thomas; Tucker, Stephen J. (1 June 2016). "Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states". Journal of General Physiology. 147 (6): 497–505. doi:10.1085/jgp.201611601. PMC 4886281. PMID 27241700.
  18. ^ Rödström, Karin E. J.; Cloake, Alexander; Sörmann, Janina; Baronina, Agnese; Smith, Kathryn H. M.; Pike, Ashley C. W.; Ang, Jackie; Proks, Peter; Schewe, Marcus; Holland-Kaye, Ingelise; Bushell, Simon R.; Elliott, Jenna; Pardon, Els; Baukrowitz, Thomas; Owens, Raymond J.; Newstead, Simon; Steyaert, Jan; Carpenter, Elisabeth P.; Tucker, Stephen J. (16 May 2024). "Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation". Nature Communications. 15 (1) 4173. Bibcode:2024NatCo..15.4173R. doi:10.1038/s41467-024-48536-2. PMC 11099193. PMID 38755204. {{cite journal}}: Check |pmc= value (help); Check |pmid= value (help)
  19. ^ Dong, Yin Yao; Pike, Ashley C. W.; Mackenzie, Alexandra; McClenaghan, Conor; Aryal, Prafulla; Dong, Liang; Quigley, Andrew; Grieben, Mariana; Goubin, Solenne; Mukhopadhyay, Shubhashish; Ruda, Gian Filippo; Clausen, Michael V.; Cao, Lishuang; Brennan, Paul E.; Burgess-Brown, Nicola A.; Sansom, Mark S. P.; Tucker, Stephen J.; Carpenter, Elisabeth P. (13 March 2015). "K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac". Science. 347 (6227): 1256–1259. Bibcode:2015Sci...347.1256D. doi:10.1126/science.1261512. PMC 6034649. PMID 25766236.
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